Authors:
Pinaki Pal,Asish Mitra,DOI NO:
https://doi.org/10.26782/jmcms.2022.03.00005Keywords:
Drug Infusion,Pharmacologic Modeling (PK),Plasma Drug concentration,Matlab,Simulation,Abstract
In the present numerical study, we apply an ODE IVP to plasma drug concentrations for a one-compartment model in presence of drug infusion. Solution procedure is done in a Matlab environment. The outcome shows that the infusion rate at time t = 4 h is discontinuous but the corresponding plasma concentration-time profile looks smooth at that time.Refference:
I. Dingyu Xue, “Solving applied mathematical problems with MATLAB,” Chapman & Hall/CRC.
II. Huixi Zou, Parikshit Banerjee, Sharon Shui Yee Leung and Xiaoyu Yan, Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges, Frontiers in Pharmacology, 2020, Volume 11, 1-15.
III. Laffleur, F. and Keckeis, V., Advances in Drug Delivery Systems: Work in Progress Still Needed? International Journal of Pharmaceutics : 2020, X, 2.
IV. Mark E. Tomlin (Ed.), Pharmacology and Pharmacokinetics A Basic Reader, Springer-Verlag London Limited 2010.
V. Rahman, M.M., Ferdous, K.S. and Ahmed, M., Emerging Promise of Nanoparticle-Based Treatment for Parkinson’s Disease. Biointerface Research in Applied Chemistry, 2020, 10, 7135-7151.
VI. Shirakura, T., et al. (2017) Matrix Density Engineering of Hydrogel Nanoparticles with simulation-Guided Synthesis for Tuning Drug Release and Cellular Uptake. ACS Omega , 2, 3380-3389.
VII. Sunil S. Jambhek, Philip J. Breen, Basic Pharmacokinetics, Pharmaceutical Press, 2nd ed. 2012.
VIII. Zhang, H., Fan, T.J., Chen, W., Li, Y.C. and Wang, B., Recent Advances of Two-Dimensional Materials in Smart Drug Delivery Nano-Systems. Bioactive Materials, 2020, 5, 1071-1086.