Authors:
Muhammad Ilyas,Mehr-e-Munir,Jehanzeb Khan,Raja Ali Riaz,DOI NO:
https://doi.org/10.26782/jmcms.2018.10.00004Keywords:
Pharmacokinetic and Pharmacodynamics mode,Sliding mode control,inear observer,sigmoid model,hypnosis,Abstract
Propofol infusion in anesthesia administration requires continual adjustment in manual drug delivery system to regulate the hypnosis level. Such regulation of hypnosis in multi-tasking surgical scenario become more challenging and risky, directs to automation in anesthesia. This paper proposes a nonlinear control based on Integral Super-twisting Sliding Mode Control (ISTMSC) of Propofol administration. The patient model is derived using pharmacokinetic and pharmacodynamics modelling based on clinical parameters, like age, height, and weight. The controller response is investigated to regulate the hypnosis level between 40 and 60 on Bispectral Index Scale (BIS). The plasma drug concentration in different compartments of the boy shows the metabolism of drugs within body. The hypnosis level is plotted for different patients shows the cortically activity of the brain required for general surgery.Refference:
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Author(s): Muhammad Ilyas, Mehr-e-Munir, Jehanzeb Khan, Raja Ali Riaz View Download